Latest
industry research report on: Global Colorectal Cancer Market : Industry
Size, Share, Research, Reviews, Analysis, Strategies, Demand, Growth,
Segmentation, Parameters, Forecasts
Colorectal cancer (CRC),
otherwise known as bowel cancer, is a malignancy originating in the
colon (the large intestine) or rectum, both of which are located towards
the end of the human gastrointestinal tract. It begins as a benign
tumor, which is almost always in the form of a small polyp within the
colon or rectum. It rarely occurs in the absence of polyps, although can
arise as a result of an inflammatory bowel disease such as Crohn’s
disease or ulcerative colitis. CRC was the third most prolific
oncological indication with regard to the number of new cases in the US
in 2016.
The
disease can be divided into two categories based on how advanced it is
upon diagnosis. These are early-stage (adjuvant) CRC, which can be
treated with surgery, and metastatic (advanced) CRC, which cannot.
Therapeutic options differ between the two treatment settings, with
therapies for adjuvant CRC aiming to prevent disease re-occurrence and
those for advanced conditions aiming to slow disease progression while
maintaining the patient’s quality of life.
Targeted
therapies have already begun to extend the lifespan of metastatic CRC
patients compared with chemotherapy-only regimens. However, there
remains an unmet need to improve the efficacy of treatment options and
extend survival for these patients. Additionally, an unmet need exists
for patients with KRAS mutation-positive CRC, for whom certain currently
marketed therapies are not recommended.
This
tabular heatmap framework, designed to provide an easily digestible
summary of these clinical characteristics, provides detailed information
on all late-stage clinical trial results for products in the CRC
market, with additional focus on the late-stage pipeline. These are
split along therapy lines, and are therefore reflective of the treatment
algorithm.
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All
safety and efficacy endpoints reported in these trials are displayed,
for both the drug and placebo groups. In addition, key study
characteristics such as the size, composition and patient segment of the
study population are provided. These results are presented in a
visually accessible, color-coded manner in order to maximize ease of
use.
The
accompanying text provides a detailed analysis of the clinical
benchmarks set by the current market landscape, and the anticipated
changes to these benchmarks, and to the treatment algorithm, as a result
of the late-stage pipeline.
Scope
- How is the colorectal cancer market landscape expected to change with regard to therapeutic type, due to promising pipeline therapies?
- What are the clinical characteristics of currently approved therapies for colorectal cancer, in terms of specific safety and efficacy parameters?
- How are clinical safety and efficacy parameters linked to the key unmet needs in this indication?
- How will current late-stage immunotherapeutics affect the colorectal cancer market, and will they be able to satisfy current unmet need with regard to effective therapy options?
- Are future product approvals likely to affect the treatment algorithm significantly?
Reasons to buy
- Understand the current clinical landscape by considering the treatment options available for earlyand late-stage disease.
- Visually compare the currently approved treatments available at each line of therapy, based on the most important efficacy and safety parameters tested in clinical trials.
- Assess the current late-stage pipeline, in terms of the likely positioning of each product and the implications for the clinical landscape at each line of therapy.
- Understand the relative strengths and weaknesses of the studies used to gather these data.
- Build up a nuanced understanding of the clinical benchmarks set by these products, and consider how the current late-stage pipeline will affect these benchmarks.
- Assess your own pipeline programs in light of these benchmarks in order to optimally position them and maximize uptake by clinicians.
Table of Contents
1 Table of Contents
1 Table of Contents 2
2 Introduction 3
2.1 Report Guidance 6
3 Marketed Products 7
3.1 Early-Stage Adjuvant Therapy 7
3.2 Advanced (Unresectable or Metastatic) Therapy 8
3.2.1 Chemotherapy 9
3.2.2 Targeted Therapies 10
4 Pipeline Products 13
4.1 Changes to Early-Stage Adjuvant Therapies, 2017–2022 13
4.2 Changes to Advanced (Unresectable or Metastatic) Therapies, 2017–2022 13
4.2.1 Changes to Chemotherapies, 2017–2022 13
4.2.2 Changes to Targeted Therapies, 2017–2022 14
5 Appendix 17
5.1 Abbreviations 17
5.2 References 18
5.3 Research Methodology 21
5.4 Contact Us 21
5.5 Disclaimer 21
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