Latest
industry research report on: Global Alzheimers Disease Market :
Industry Size, Share, Research, Reviews, Analysis, Strategies, Demand,
Growth, Segmentation, Parameters, Forecasts
Alzheimers disease (AD)
is an irreversible, progressive neurodegenerative disease,
characterized by cognitive impairment, memory loss and functional
decline. The pathological features of AD comprise a complex set of
histopathological changes within the brain. Symptoms typically begin to
first appear in patients in their mid-sixties, and appear in varying
stages. The effects of AD, particularly at an advanced stage, are
devastating to patients and their caregivers, and are associated with
significant associated healthcare costs.
Current
treatments focus on sustaining the patient?s cognitive function,
managing behavioural symptoms and slowing down the rate of disease
progression. There is currently no cure for AD, and only six symptomatic
treatment therapies have been approved, of which one (Cognex) is no
longer available in the US. The current market leaders are suboptimal in
terms of efficacy, and there is therefore a large unmet need within AD
to develop safer and more efficacious treatments.
There
are numerous differences between many of these products due to their
mechanisms of action, and these must be understood fully by companies
seeking to position a novel drug in this market. This tabular heatmap
framework, designed to provide an easily digestible summary of these
clinical characteristics, provides detailed information on all
late-stage clinical trial results for products in the AD market and
Phase III pipeline. These are split along therapy lines, and are
therefore reflective of the treatment algorithm.
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All
safety and efficacy endpoints reported in these trials are displayed,
for both the drug and placebo groups. In addition, key study
characteristics such as the size, composition and patient segment of the
study population are provided. These results are presented in a
visually accessible, color-coded manner in order to maximize ease of
use.
The
accompanying text provides a detailed analysis of the clinical
benchmarks set by the current market landscape, and the anticipated
changes to these benchmarks, and to the treatment algorithm, as a result
of the late-stage pipeline.
Scope
- What preventative early-stage drugs are generating interest within the AD pipeline?
- Will the current AD market landscape ensure that the first drug with a disease-modifying mechanism of action will become the market leader?
- What are the clinical characteristics of currently approved therapies for AD, in terms of specific safety and efficacy parameters?
- What are the key unmet needs in this indication, and which clinical safety and efficacy parameters are the most closely linked to them?
- How will current late-stage molecules affect the market for AChEIs, and are they able to yield comparable clinical efficacy results?
- With three amyloid inhibitors present in the late-stage pipeline, do they have sufficient differentiating characteristics from previous clinical failures from this class to have an impact on the market?
Reasons to buy
- Understand the current clinical landscape by considering the treatment options available by drug class.
- Visually compare the currently approved treatments available by drug class, based on the most important efficacy and safety parameters tested in clinical trials.
- Assess the current late-stage pipeline, in terms of the likely positioning of each product and the implications for the clinical landscape at each line of therapy
- Understand the relative strengths and weaknesses of the studies used to gather these data.
- Build up a nuanced understanding of the clinical benchmarks set by these products, and consider how the current late-stage pipeline will affect these benchmarks.
- Assess your own pipeline programs in light of these benchmarks in order to optimally position them and maximize uptake by clinicians.
Table of Contents
1 Table of Contents
1 Table of Contents 2
2 Introduction 3
2.1 GBI Research Report Guidance 5
3 Marketed Products 6
3.1 Acetylcholinesterase Inhibitors 6
3.2 NMDAs 7
3.3 Combination therapy 7
4 Pipeline Products 8
5 Appendix 14
5.1 Abbreviations 14
5.2 References 14
5.3 Research Methodology 17
5.4 Contact Us 17
5.5 Disclaimer 17
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